Zofran® (ondansetron) is a medication that prevents nausea and vomiting caused by chemotherapy, radiation or surgery. It blocks substances in your body that can cause nausea and vomiting.
Ondansetron is used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery. Ondansetron is in a class of medications called serotonin 5-HT3 receptor antagonists. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting.